Fipronil Spray kills fleas, ticks, and biting lice on both cats and dogs.

Generic Frontline


Fiprofort , ASPIS , Protektor Spray

100ml, 250ml

Sava Medica, Cipla


0.25% w/v



I. Introduction

Brief Overview of Fipronil

Fipronil, a used insecticide from the phenylpyrazole chemical family, is extensively used in medical and agricultural fields.

Objective of the Article

This detailed article seeks to clarify the different aspects of Fipronil, including its chemical makeup, various applications, and potential adverse effects.

Importance in Modern Medicine and Pest Control

Fipronil plays a role in both medicine and agriculture, effectively combating various ectoparasites and pests. It is a component in strategies for pest control and veterinary care.

II. Composition of Fipronil

Chemical Structure

Fipronil, a chemical compound, possesses a structure that includes a trifluoromethylsulfinyl group. This particular group is essential in determining its effectiveness and stability.

Active and Inactive Ingredients

The main component of Fipronil is Fipronil itself, while there are ingredients like Ethanol and propylene glycol, among others, that are inactive. Different versions of Fipronil have ratios of these ingredients.

Different Formulations

You can find fipronil in forms, including sprays, gels, and tablets.

III. How Fipronil Works

Mechanism of Action

Fipronil blocks the chloride channels in the system of insects, which causes excessive stimulation and eventually leads to their elimination.

Target Pests and Parasites

  • Fleas
  • Ticks
  • Cockroaches
  • Ants

Speed and Duration of Effectiveness

The initial effects of the action begin within an hour and can last for several weeks, depending on the specific formulation used.

IV. Approved Uses of Fipronil

Pest Control in Agriculture

  • Grain protection
  • Soil treatment

Treatment of Fleas and Ticks in Pets

Fipronil is a phenylpyrazole antiparasitic agent that is commonly used to treat and control chewing lice in dogs, puppies, kittens, and cats. It also aids in the control of sarcoptic mange infestations in dogs and has been used to treat Cheyletiellosis (Walking Dandruff Mite) in dogs and cats 1Fipronil is also used as an external antiparasitic to treat and prevent infestation by ectoparasites or external parasites such as fleas, lice, and ticks in cats 2It is sometimes used in conjunction with flea development inhibitors such as pyriproxyfen or metroprene to increase efficacy against fleas in immature stages 2.

1PetPlace 2AnimalWised

Other Veterinary Applications

Fipronil is a broad use insecticide that belongs to the phenylpyrazole chemical family. It is used to control ants, beetles, cockroaches, fleas, ticks, termites, mole crickets, thrips, rootworms, weevils, and other insects. Fipronil is more toxic to insects than people and pets because it is more likely to bind to insect nerve endings. It works by disrupting the normal function of the central nervous system in insects 1.

There are more than 50 registered products that contain fipronil. It is used in various pesticide products, including granular products for grass, gel baits, spot-on pet care products, liquid termite control products, and products for agriculture 1.

Regarding the use of fipronil in protecting livestock and birds, there are limited situations where it can be used. For example, fipronil can be used to control fleas and ticks on dogs and cats 2However, it is not recommended for use on livestock animals such as cows or pigs 1.

Learn more:

V. Off-Label Uses of Fipronil

Fish Farming

Fipronil is a pesticide that is used in the aquaculture industry to address the issue of parasitic infestations 1. For more information on the use of Fipronil in aquaculture, you can refer to the following reference:

  • Buchmann, K. (2022). Control of parasitic diseases in aquaculture. Parasitology, 149(Special Issue 14: Fish Parasitology), 1985-1997. doi: 10.1017/S00311820220010931

Garden Pest Control

Fipronil is a pesticide that is highly effective in getting rid of garden pests such as aphids and beetles 1. For more information on the use of Fipronil as a pesticide, you can refer to the following reference:

Precautions for Off-Label Use

It is advisable to seek guidance from experts regarding the dosages and safety precautions.

VI. Dosage and Administration

  • Pets: 10-20 mg/kg
  • Agriculture: 100-200 grams per acre

Methods of Administration

Dosage Adjustments and Special Conditions

Adjust the dosage for patients with kidney or liver problems. Seek guidance from a healthcare professional for individualized recommendations.

VII. Administration to Specific Populations

Administration to Elderly

That's not applicable because Fipronil is not meant to be used by humans.

Administration to Pregnant Women and Nursing Mothers

Likewise, not intended for human consumption.

Administration to Children

If you have pets it's important to consult a veterinarian to get the dosage and take necessary precautions based on their age.

VIII. Side Effects and Common Side Effects

Classification of Side Effects

  • Acute
  • Chronic

Commonly Reported Side Effects

Pets often experience skin irritation, while excessive usage of it in agriculture can lead to a decrease in crop yield.

How to Manage Side Effects

Stop using the product and seek advice from a professional for appropriate symptomatic care.

IX. Interaction with Other Substances

Drug Interactions

It has been observed to have effects when combined with other insecticides, like organophosphates.

Food and Alcohol Interactions

Fipronil is not meant to be consumed by humans, so ingestion is irrelevant in this case.

What to Avoid When Taking Fipronil

Avoid using pesticides or insecticides simultaneously.

X. Warnings and Contraindications

Situations Where Fipronil Should Not Be Used

Fipronil should not be used in specific situations, including Pets with a known hypersensitivity to phenylpyrazole compounds. Environments where endangered insect species are found. Food-producing animals, as it may have a lasting impact. Please note that these circumstances require consideration when using Fipronil.

Potential Risks and Complications

The impact on the system of species that are not the intended target The potential for environmental pollution if not adequately controlled The risks of causing birth defects when used in areas where pregnant animals are often present

XI. Careful Administration and Important Precautions

Monitoring and Follow-up

It is essential to conduct administration monitoring. For pets, it is recommended to schedule a consultation within one week following the medication administration.

Allergic Reactions and Sensitivities

If you experience any signs of reactions, such as redness, itching, or difficulty breathing, it is essential to seek immediate consultation with healthcare professionals.

Safe Use Guidelines

Remember to wear gloves when applying the product. After you're done, make sure to wash your hands. Also, try to minimize contact, with your skin and eyes while using it.

XII. Handling Precautions and Storage

Proper Storage Conditions

Please make sure to store the product in a location that's cool and dry. Ensuring the cap is securely closed and tightly sealed is essential. Remember to keep it from children and pets where they cannot reach it.

Disposal Instructions

Please make sure to dispose of any empty or partially used containers in compliance with the environmental regulations that apply in your local area.

Safety Measures When Handling Fipronil

Please refrain from consuming Take care to avoid inhaling any fumes Ensure usage takes place in ventilated spaces.

XIII. Overdosage and Its Management

Symptoms of Overdose

Pets may exhibit symptoms such as tremors, seizures, and a loss of coordination.

Immediate Steps to Take

Please stop the administration. Please seek attention without any delay.

Long-Term Management and Care

Keep an eye out for any long-term impacts on the nervous system or overall health. Make sure to follow the guidance of a healthcare expert when it comes to adjusting dosages in the future.

XIV. Conclusion

Summary of Key Points

Fipronil is an insecticide with many uses, including in agriculture and veterinary treatments. However, it is essential to follow safety protocols when using it due to specific considerations.

Recommendations for Safe and Effective Use

It is essential to follow the suggested dosages as recommended. Seek advice from experts regarding any uses of the recommended ones. Take care when handling and storing to minimize risks and complications.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by lech on Oct 19, 2017 Verified Purchase

Generic Frontline

Exactly as described, good product, quick ship

Note: does not imply any medical claims from this review.
Posted by lech on Oct 2, 2017 Verified Purchase

Frontline, Fipronil Spray

came in excellent condition -- no problems !!!!

Note: does not imply any medical claims from this review.

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