Nise Gel

Nise Gel (Nimesulide/ Methyl Salicylate/ Menthol/ Capsaicin) is applied to help treat certain acute or chronic musculoskeletal conditions, such as soft tissue injuries or nonarticular rheumatic disorders, which include muscular discomfort, backaches, tendinitis, etc.

Nise Gel

Nimesulide/ Methyl Salicylate/ Menthol/ Capsaicin

Nise Gel


Dr Reddy's Laboratories



Nise Gel

1. Introduction

Overview of Nise Gel

Nise Gel, well known for its pain-relieving and anti-inflammatory effects, is a key solution for managing pain topically. This gel formula is crafted to offer relief from different musculoskeletal pains.

Brief history and development

After research in pharmacology, Nise Gel was launched in the pharmaceutical market to provide a safer topical treatment option compared to oral painkillers that frequently cause issues in the gastrointestinal system.

Importance in pain management

  • Immediate action at the site of pain
  • Minimizes systemic side effects
  • Enhances patient compliance and convenience

2. Composition and Active Ingredients

Detailed breakdown of ingredients

The gel contains a mix of diclofenac diethylamine and other substances that help the drug absorb better and stay effective. The effectiveness of diclofenac is boosted by solubilizers and penetration enhancers in the gel.

Role of each ingredient in efficacy

Each ingredient in Nise Gel is carefully chosen to ease pain and swiftly and efficiently lessen inflammation. The additional substances, though inactive, aid diclofenac's deeper absorption into the subcutaneous tissue, speeding up the relief of pain, like lidocaine.

Diclofenac Diethylamine vs Diclofenac sodium

Each gram of the gel includes 10 milligrams of sodium which is the same as 11.6 milligrams of diclofenac diethylammonium. Additionally, the gel contains excipients; 0.5 milligrams of propyl hydroxybenzoate, 0.5 milligrams of methyl hydroxybenzoate, and 80 milligrams of propylene glycol are present in each gram of the gel.

3. How Nise Gel Works

Mechanism of action

Nise Gel works by blocking the cyclooxygenase (COX) enzymes, which play a role in producing prostaglandins substances that cause inflammation and pain. Stopping these enzymes from working in the gel reduces inflammation. Eases pain in the specific area it is applied to.

Pharmacodynamics and pharmacokinetics

The way Nise Gel works shows that it helps reduce inflammation in an area without spreading too much throughout the body. This means that the medicine can target the area effectively while keeping the overall exposure low to prevent unwanted side effects.

4. Uses of Nise Gel

Approved therapeutic uses

Symptoms and conditions treated

The gel is good at handling issues such as swelling, stiffness and pain in the joints. It is also effective, for treating bouts of musculoskeletal pain caused by injuries and ongoing conditions.

5. Off-Label Uses of Nise Gel

Exploring non-approved uses

Nise Gel is typically prescribed for pain and inflammation. It is sometimes used in ways that are not officially endorsed. Despite lacking approval, anecdotal evidence and early clinical studies suggest that it may be effective in addressing other health issues.

Evidence supporting off-label applications

Recent studies indicate that Nise Gel could offer advantages in conditions like tendinitis and nerve pain especially when standard therapies have not produced desired results. Insights from tests and feedback, from patients are building a stronger body of proof backing these unconventional uses.

6. Dosage and Administration

The amount of Nise Gel to use differs based on the condition being addressed. When dealing with musculoskeletal issues it is advised to apply a thin layer of gel to the affected area three to four times a day. It's crucial not to go beyond the suggested dosage to prevent any negative outcomes.

Methods of application

Gently massage an amount of Nise Gel onto the affected area of the skin, ensuring it covers the targeted spot without any leftover residue.

Duration of use guidelines

  • It's advisable to use it for a short period, usually no more than two weeks.
  • If the symptoms continue after this time, it's best to seek advice from a healthcare provider to prevent any complications.

7. Side Effects of Nise Gel

Common side effects

Users might notice some to moderate irritation on their skin when they apply the product, such as redness, itching, or a sensation of burning.

Rare but serious side effects

On occasion, individuals may experience severe allergic reactions, like anaphylaxis or breathing problems requiring prompt medical intervention.

Managing side effects

Side effects can sometimes be controlled by using the gel frequently or stopping its use altogether. If severe reactions occur, it is important to stop using the gel and seek advice from a healthcare provider.

Diclofenac side effects weight gain

Signs that could indicate side effects while using this medication may consist of dark tar like stools, reduced urine output, intense abdominal discomfort, a skin rash, puffiness, in the facial area or extremities unusual bleeding or bruising atypical weight increase and vomiting blood.

8. Important Precautions

Who should not use Nise Gel

People who have allergies to diclofenac or any of the gel's ingredients should not use it. Those with kidney or liver issues should also avoid taking this medication.

Precautions for specific populations

  • During the stages of pregnancy, it's advisable for expectant mothers to avoid using Nise Gel as it could have negative impacts on the heart development of the fetus.
  • Individuals with a background of bleeding or ulcers should approach the use of this gel with care.

9. Warnings and Contraindications

Detailed contraindications

Patients with peptic ulcers should avoid taking Nise Gel as it could worsen their condition. It is also not recommended for individuals who have had asthma attacks, hives, or allergic reactions to aspirin or other NSAIDs.

Potential risks and warnings

Prolonged usage of Nise Gel might heighten the chances of liver and kidney issues. It's important to keep an eye, on patients for any indications of liver or kidney problems.

Diclofenac and alcohol

It's important not to consume alcohol when you're using diclofenac. Drinking alcohol can heighten the chances of stomach bleeding as a side effect of diclofenac.

  • If you experience any signs of stomach or intestinal bleeding, such as bloody or tar-like stools, or if you cough up blood or vomit that resembles coffee grounds, contact your doctor immediately.

10. Interactions With Other Medications

Common drug interactions

Nise Gel could potentially raise the chance of bleeding when taken alongside anticoagulants like warfarin. Using it together with topical medications might affect how well each product gets absorbed.

Interaction mechanisms and management

When dealing with these interactions it's best to space out the use of topical medications over several hours and keep an eye out for any negative effects. Making sure to inform your healthcare provider about all the medications you're taking simultaneously is essential, for planning treatment.

Diclofenac vs Ibuprofen

Diclofenac is considered to be a NSAID compared to ibuprofen. It is recommended to take diclofenac 2 3 times a day for relief, from arthritis pain. In the case of using ibuprofen for pain a higher dosage often referred to as a "prescription strength dose " is typically required.

Meloxicam vs Diclofenac

Meloxicam has a half-life of 20 hours, while diclofenac's half-life is only 2 hours. The half-life represents the duration it takes for the drug's quantity to decrease by half. Consequently, meloxicam remains in the system for a period, allowing for once-daily dosing.

11. Special Considerations

Administration to elderly patients

Elderly individuals frequently show increased reactions to drugs like Nise Gel, which requires a dosage strategy. It is advisable to apply the gel in moderation and keep a watch for potential overall side effects, such as kidney problems or stomach-related issues.

Use in pregnant women and nursing mothers

Nise Gel is typically not recommended for use during pregnancy in the final trimester as it may pose a risk of fetal heart problems. It is advisable, for nursing mothers to steer clear of the gel since it can transfer into breast milk and potentially affect the babys well being.

Guidelines for pediatric use

  • Not suitable for kids under the age of 12.
  • It is to be used with careful medical oversight for teenagers.

12. Overdosage and Emergency Management

Signs of overdose

Signs of taking much Nise Gel can lead to intense skin discomfort, a faster heartbeat and breathing problems. While its uncommon systemic reactions might happen, especially if you use amounts, on widespread areas of injured skin.

Steps for immediate management

If someone overdoses, stop using the gel away and wipe off any extra from the skin. Get medical help to handle symptoms and avoid further issues.

Long-term concerns

Repeated improper use may result in adverse reactions notably impacting the liver and kidneys. Continuous observation might be necessary for individuals who have encountered a dosage.

How long does diclofenac stay in your system

The medication usually peaks in the body around 10 to 14 hours after application. Diclofenac sodium, found in Voltaren gel, can remain in the body for up to three weeks.

13. Storage and Handling Precautions

Optimal storage conditions

Make sure to store Nise Gel at room temperature from direct sunlight and moisture to maintain its effectiveness and prevent it from deteriorating.

Handling precautions to maintain efficacy

Remember to seal the tube when you're not using it. Prevent the gel from getting contaminated by maintaining cleanliness in the application area and avoiding contact with the nozzle.

14. Careful Administration and Safety Measures

Safe application techniques

Remember to use hands when applying Nise Gel gently massage it into the skin until its absorbed. Make sure the skin is clean and dry, before applying to get the absorption and therapeutic benefits.

Avoiding common mistakes

  • Do not put the gel on cuts or infected areas to avoid making them worse or having it enter your body.
  • Only use airtight dressings if a doctor tells you to, as they could make the gel absorb more and cause side effects.

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