Pentoxifylline ER

Trental Extended-Release (Pentoxifylline) is prescribed to help improve blood flow in individuals with poor circulation in the hands and feet. It helps minimize pain in the extremities due to poor blood circulation.

Generic Trental




Aventis, Sanofi, Sun Pharma

Extended Release Tablet

400 mg

Turkey, India

Pentoxifylline ER

I. Introduction

Overview of Pentoxifylline ER

Pentoxifylline ER, also known as Extended Release, is a medication used to manage vascular conditions. It works by enhancing blood circulation and decreasing blood thickness to aid in treatment.

Brief history and development of the medication

Pentoxifylline, created in the early 20th century, was initially extracted from xanthine, a purine base present in various tissues and fluids within the human body.

Importance of understanding its uses and precautions

Having a grasp of the uses of Pentoxifylline ER and its safety characteristics is essential for optimizing its healing advantages while minimizing any possible drawbacks.

II. Composition and Characteristics

Active ingredients and formulation

The main component in Pentoxifylline ER is pentoxifylline, which is blended into a slow-release formula to ensure extended levels in the bloodstream.

Different available forms and strengths

Pentoxifylline ER comes in forms such as 400 mg extended-release tablets, which can be customized for treatment plans according to individual patient requirements.

III. How Pentoxifylline ER Works

Mechanism of action

The medication works by blocking phosphodiesterase, which results in levels of cAMP in the walls of blood vessels. This leads to vasodilation and enhances microcirculation.

Effects on blood flow and oxygen delivery

By improving the flexibility of blood cells and reducing the thickness of blood Pentoxifylline ER helps in delivering oxygen to tissues, which is crucial for treating diseases such, as peripheral arterial disease.

IV. Approved Uses of Pentoxifylline ER

Indications in vascular health

It is commonly recommended for addressing issues related to blood circulation, such as peripheral artery disease and recovery, from a stroke.

Treatment of peripheral arterial disease

This treatment works well in easing the signs of claudication like discomfort and cramps, in the legs leading to walking abilities and overall well being.

Management of intermittent claudication

Pentoxifylline ER has demonstrated effectiveness, in alleviating intermittent claudication symptoms enabling individuals to engage in extended periods of walking without experiencing pain.

V. Off-Label Uses of Pentoxifylline ER

VI. Dosage and Administration

General dosing guidelines

The typical recommended dose of Pentoxifylline ER is 400 mg taken thrice daily although the dosage might differ depending on the seriousness of the ailment being addressed.

Adjustments for specific conditions

Patients who have kidney issues or are, at a risk of side effects may need to have their medication doses adjusted.

Administration techniques and best practices

Remember to take the extended release tablets along with meals to improve absorption and minimize any stomach related discomfort.

VII. Administration to Special Populations

A. Administration to Elderly Patients

Elderly individuals might need changes in medication dosage depending on their kidney function and general well-being.

B. Administration to Pregnant Women and Nursing Mothers

Although Pentoxifylline ER falls within FDA pregnancy category C, it should be reserved for situations where it is deemed necessary and after an evaluation of risks and benefits.

C. Administration to Children

The safety and efficiency of Pentoxifylline ER in children have not been confirmed. It is important to proceed with caution and seek advice from experts.

VIII. Side Effects and Adverse Reactions

A. Common Side Effects

  • Pentoxifylline ER, similar to medications, may cause some mild side effects. Some mentioned ones are feeling dizzy and experiencing headaches as well as gastrointestinal issues, like nausea and vomiting.
  • Additionally, patients might notice flushing and palpitations.
  • To help manage these side effects, it is recommended that patients follow the dosages closely and consider taking the medication with meals to lessen any stomach discomfort.

B. Serious Adverse Effects

  • Although uncommon, specific negative outcomes could present health concerns, such as severe allergic reactions, liver and kidney issues, and low platelet levels.
  • If these signs occur, seeking medical assistance is crucial.
  • Ongoing observation and extended assessment might be necessary to understand and address serious health consequences.

IX. Drug Interactions

Pentoxifylline ER could interact with medications and substances, leading to changes in its efficacy and safety profile.

Potential interactions with common medications

Frequent scenarios involve chances of bleeding when taking blood thinners such as warfarin, heightened risk of low blood pressure with medications for high blood pressure, and potential disruptions in the breakdown of other drugs managed by liver enzymes.

Interaction with food and dietary substances

During treatment, it is recommended that patients limit their intake of caffeine as it can intensify the stimulating effects of pentoxifylline, potentially causing heart rate and feelings of anxiety.

Managing and avoiding harmful interactions

Patients should always make sure to give their healthcare provider a list of all the medications they are currently taking, including any over-the-counter drugs and herbal supplements to prevent any harmful interactions. It may also be important to have their drug levels checked regularly.

X. Precautions and Warnings

A. Important Precautions

It's important to monitor key blood levels in patients taking Pentoxifylline ER, especially if they have liver or kidney issues. Depending on the results of these tests, changes to the treatment might be needed.

B. Contraindications

Patients should avoid taking Pentoxifylline ER if they have experienced cerebral or retinal hemorrhages, severe cardiac arrhythmias, or if they are known to be hypersensitive to Pentoxifylline or any of its ingredients.

C. Handling and Storage Precautions

It's important to store Pentoxifylline ER to keep it effective. Store the medication at room temperature in a place away from sunlight. When disposing of it, make sure to follow the rules for safety reasons.

XI. Managing Overdosage

In the event of an overdose, patients might show signs like low blood pressure, seizures, and potentially life-threatening breathing difficulties.

  • It is crucial to seek medical help and provide the necessary support, including any antidotes that may be on hand. Ongoing care is essential to assist the patient in recovering and avoiding any lasting health issues.

Rated: 5.0 / 5 based on 5.0 customer reviews.

Posted by Hawke on Apr 1, 2018 Verified Purchase

Great Product

Great product, works the same as what I receive from my pharmacy in the U.S. Fast shipping and great communication. One can even speak with a rep. on the phone, they will even call should there be a reason to. Emails are answered in under an hour. Great products & customer service all around...and I have been a customer for at least a decade.

Note: does not imply any medical claims from this review.

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